David A Haake Selected Research

Leptospirosis

12/2020	GspD, The Type II Secretion System Secretin of Leptospira, Protects Hamsters against Lethal Infection with a Virulent L. interrogans Isolate.
1/2017	Immunoprotective properties of recombinant LigA and LigB in a hamster model of acute leptospirosis.
1/2016	The Miller Hypothesis.
1/2015	Leptospirosis in humans.
10/2014	Identification of cell-binding adhesins of Leptospira interrogans.
10/2014	Post-translational modification of LipL32 during Leptospira interrogans infection.
12/2011	A LigA three-domain region protects hamsters from lethal infection by Leptospira interrogans.
6/2011	Heterologous expression of pathogen-specific genes ligA and ligB in the saprophyte Leptospira biflexa confers enhanced adhesion to cultured cells and fibronectin.
2/2011	The multifunctional LigB adhesin binds homeostatic proteins with potential roles in cutaneous infection by pathogenic Leptospira interrogans.
11/2010	Transcriptional response of Leptospira interrogans to iron limitation and characterization of a PerR homolog.

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David A Haake Research Topics

Disease

22	Infections 12/2020 - 05/2002
19	Leptospirosis 12/2020 - 01/2002
3	Wounds and Injuries (Trauma) 02/2011 - 01/2010
2	Urinary Tract Infections (Urinary Tract Infection) 01/2022 - 12/2011
2	Communicable Diseases (Infectious Diseases) 01/2022 - 11/2020
2	Sepsis (Septicemia) 11/2020 - 11/2014
2	Uveitis 03/2012 - 11/2005
1	Bacterial Infections (Bacterial Infection) 01/2022
1	Candidiasis (Moniliasis) 11/2020
1	Candidemia 11/2020
1	Endocarditis 11/2020
1	Bacteremia 11/2020
1	Meningitis 11/2020
1	Syphilis 06/2020
1	Spirochaetales Infections 01/2018
1	Cytokine Release Syndrome 01/2015
1	Weight Loss (Weight Reduction) 11/2014
1	Neurogenic Urinary Bladder (Bladder, Neurogenic) 12/2008
1	Autistic Disorder (Autism) 09/2002
1	Interstitial Nephritis (Tubulointerstitial Nephritis) 01/2002

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2003
9	VaccinesIBA 12/2020 - 08/2007
6	AntibodiesIBA 01/2018 - 01/2002
6	Immunoglobulins (Immunoglobulin)IBA 01/2017 - 05/2007
5	Anti-Bacterial Agents (Antibiotics)IBA 01/2022 - 03/2008
4	AntigensIBA 01/2018 - 08/2003
4	Lipoproteins (Lipoprotein)IBA 01/2018 - 05/2003
3	Subunit VaccinesIBA 01/2017 - 08/2007
3	Membrane Proteins (Integral Membrane Proteins)IBA 05/2007 - 05/2002
2	Virulence Factors (Pathogenicity Factors)IBA 06/2011 - 09/2010
2	Immunoglobulin M (IgM)IBA 03/2008 - 05/2007
1	Secretin FDA Link 12/2020
1	Type II Secretion SystemsIBA 12/2020
1	Synthetic Vaccines (Recombinant Vaccines)IBA 12/2020
1	CoagulaseIBA 11/2020
1	CytokinesIBA 06/2020
1	PorinsIBA 01/2016
1	Interleukin-6 (Interleukin 6)IBA 01/2015
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2015
1	Interleukin-10 (Interleukin 10)IBA 01/2015
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2014
1	Biomarkers (Surrogate Marker)IBA 11/2014
1	Bacterial AdhesinsIBA 10/2014
1	Lysine (L-Lysine)FDA Link 10/2014
1	Peptides (Polypeptides)IBA 10/2014
1	Cadherins (E-Cadherin)IBA 10/2014
1	EpitopesIBA 10/2014
1	16S Ribosomal RNAIBA 12/2011
1	trans-sodium crocetinate (crocetin)IBA 12/2011
1	Fibrinogen (Factor I)FDA Link 02/2011
1	LipopolysaccharidesIBA 02/2011
1	Collagen Type III (Type III Collagen)IBA 02/2011
1	Fibronectins (Fibronectin)IBA 02/2011
1	FibrinIBA 02/2011
1	polycarbonateIBA 01/2011
1	PolymersIBA 01/2011
1	IronIBA 11/2010
1	ElastinIBA 09/2010
1	LigandsIBA 05/2007
1	DNA (Deoxyribonucleic Acid)IBA 11/2005
1	Immune Sera (Antisera)IBA 11/2005
1	Primaquine FDA Link 02/2005
1	Amino Acids FDA Link 08/2003
1	Vancomycin FDA LinkGeneric 09/2002
1	Formaldehyde (Formol)FDA Link 01/2002
1	SilverIBA 01/2002

Therapy/Procedure

3	Therapeutics 11/2020 - 12/2008
1	Lasers (Laser) 01/2011
1	Debridement 01/2010
1	Chemoprevention 05/2002